According to reports from Leadership, the explosion occurred at 2.45pm this afternoon. The number of casualties could not be ascertained as at the time of this report.
The female bomber blew herself up as students queued to check their names on a new admission list, they reported.
This is the fifth attack in Kano since Sunday, at least three of which have been carried out by female bombers.
Militant Islamist group Boko Haram has been widely blamed for the attacks.
It has waged an insurgency in Nigeria since 2009, and appears to have adopted a new tactic by increasingly using female suicide bombers, correspondents say.
The bomber was hidden in the crowd, a witness, Isyaku Adamu, told the AFP news agency.
"It was a huge crowd and people were jostling to go through the lists," Mr Adamu is quoted as saying.
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